Acetone → HCID 12800061, compound

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Reaction Steps

A charge containing 0.1 moles of mercaptoethanol, 0.1 moles of 85% potassium hydroxide and 250 ml of acetone is stirred for 10 minutes. To this stirred mixture is added 0.1 moles of 2-oxo-3-benzothiazolineacetyl chloride in one portion. An exothermic reaction set in causing a temperature rise from 30° to about 40° C. After stirring for about 24 hours at room temperature, 500 ml of water and 500 ml of ethyl ether are added and stirring continued at 25°-30° C. for 15 minutes. The separated ether layer is washed with water until neutral to litmus and dried over sodium sulfate. The ether is removed in vacuo at a maximum temperature of 80°-90° C. at 1-2 minutes. Analytical data is summarized in Table I, below.

Provenance & Evidence