HCID 12917674, compound → HCID 12917673, compound

HRID 1660446Notes

Reaction equation

HRID 1660446 reaction equation
[CH3:1][S:2][C:3]([C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:25])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[C:22](O)=[O:23])=[CH:10][CH:9]=1)([CH3:7])[C:4]([OH:6])=[O:5]>C(O)(=O)C>[CH3:1][S:2][C:3]([C:8]1[CH:9]=[CH:10][C:11]([N:14]2[C:15](=[O:25])[C:16]3=[CH:21][CH:20]=[CH:19][CH:18]=[C:17]3[C:22]2=[O:23])=[CH:12][CH:13]=1)([CH3:7])[C:4]([OH:6])=[O:5]

Participants

3

Reactant 1

HCID 12917674HCID 12917674, compound

Product 1

HCID 12917673HCID 12917673, compoundYield 96.6%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

α-Methylthio-α-[p-(o-carboxybenzoylamino)phenyl]propionic acid (146 mg) was dissolved in 1 ml of acetic acid, and the solution was heated under reflux for 3 hours. Acetic acid was removed under reduced pressure to afford 134 mg of α-methylthio-α-(p-phthalimidophenyl)propionic acid as colorless crystals.

Workup

  1. temperaturethe solution was heated
  2. temperatureunder reflux for 3 hours
  3. customAcetic acid was removed under reduced pressure

Sources & evidence

ORD record
ord-a0b5c744ec5f4e17b7699cb788e4fab4
Source dataset
uspto-grants-1981_12
Patent number
US04308208

Reaction notes

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