Methanol → HCID 178494552, compound

Participants

Reaction Steps

Sodium methylate (13.5 g, 0.25 mole) was added to a solution of chloroacetamidine hydrochloride (7.74 g, 0.06 mole) and ethyl 4-chloroacetoacetate (9.88 g, 0.06 mole) in methanol (100 ml) with stirring at a temperature between 10° C. and 15° C. The mixture was stirred for 1 hour at 25° C. and then refluxed for 3 hours with stirring. After the reaction mixture was cooled to room temperature, the precipitate was filtered, and the filtrate was treated in the same manner as in Reference Example 1 to obtain 6.6 g of 2,6-bis(methoxymethyl)-4-hydroxypyrimidine.

Provenance & Evidence