Methylhydrazine → HCID 86738179, compound

HRID 1660482Notes

Reaction equation

HRID 1660482 reaction equation
C[O:2][C:3]([P:5]([OH:8])([OH:7])=[O:6])=O.[CH3:9][NH:10][NH2:11]>O.CO.C(O)C>[CH3:9][N:10]([C:3]([P:5]([OH:8])([OH:7])=[O:6])=[O:2])[NH2:11]

Participants

6

Reactant 2

HCID 6061MethylhydrazineHCID 10866411Methoxycarbonylphosphonic Acid

Product 1

HCID 86738179HCID 86738179, compoundYield 38%

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

46 parts by weight of Na2 -salt of phosphonoformic acid methyl ester are dissolved in 90 parts by volume of water and 46 parts by weight of methyl hydrazine are added at 25° C. The mixture is stirred at 80° C. for 7 hours and allowed to cool. The residue is removed by suction filtration and the filtrate is evaporated in vacuo. The residue after evaporation is digested with ethyl alcohol and the such obtained crystals are again dissolved in a mixture of 70 parts by volume methanol and 200 parts by volume ethyl alcohol and thereafter precipitated. 90 parts by weight of Na2 -salt of phosphonoformic acid methyl hydrazide are obtained (yield 38%).

Workup

  1. additionare added at 25° C
  2. temperatureto cool
  3. customThe residue is removed by suction filtration
  4. customthe filtrate is evaporated in vacuo
  5. customThe residue after evaporation
  6. customthe such obtained crystals
  7. customprecipitated

Sources & evidence

ORD record
ord-6805768c8a644f528dfafe0e62ab0cd6
Source dataset
uspto-grants-1981_12
Patent number
US04308263

Reaction notes

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