HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Bis(2-chloroethyl)-2-methoxyaniline → 1,2,3,4-Tetrahydro-6-hydroxy-2-[4-(2-methoxyphenyl)-1-piperazinyl]-naphthalene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Bis(2-chloroethyl)-2-methoxyaniline | HCID 227137 | — |
| Reactant | 6-Amino-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 13177879 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1,2,3,4-Tetrahydro-6-hydroxy-2-[4-(2-methoxyphenyl)-1-piperazinyl]-naphthalene | HCID 20556814 | — |
Reaction Steps
2.48 g of N,N-Di(2-chloroethyl)-2-methoxyaniline are dissolved together with 1.63 g of 2-amino-1,2,3,4-tetrahydro-6-hydroxynaphthalene in 100 ml of ethanol and finally refluxed for 20 hours. The solvent is evaporated off and the residue recrystallized from methanol/ether to yield the title compound. M.P. 282°-286° [Hydrochloride salt form].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04308266 |
| Source dataset | uspto-grants-1981_12 |
| ORD ID | ord-cae9cf9f7e7c4e7684699a47f1e0a275 |
| Source note | uspto-grants-1981_12 |