Acetic Anhydride → HCID 20556817, compound

HRID 1660489Notes

Reaction equation

HRID 1660489 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([N:12]1[CH2:17][CH2:16][N:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH3:25])[CH2:14][CH2:13]1)[CH2:6][CH2:5]2.[C:26](OC(=O)C)(=[O:28])[CH3:27]>N1C=CC=CC=1>[C:26]([O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([N:12]1[CH2:13][CH2:14][N:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH3:25])[CH2:16][CH2:17]1)[CH2:6][CH2:5]2)(=[O:28])[CH3:27]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 205568141,2,3,4-Tetrahydro-6-hydroxy-2-[4-(2-methoxyphenyl)-1-piperazinyl]-naphthalene

Product 1

HCID 20556817HCID 20556817, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

170 mg of 1,2,3,4-tetrahydro-6-hydroxy-2-[4-(2-methoxyphenyl)-1-piperazinyl]-naphthalene are added to 2 ml of pyridine, 70 μl of acetic anhydride are added dropwise and the solution left to stand at room temperature for 3 hours. The reaction solution is finally evaporated to dryness, the residue taken up in ethyl acetate, washed with IN sodium carbonate solution, dried and evaporated to dryness. The raw title product so obtained is converted to the hydrochloride salt form and recrystallized from methanol/ether. M.P. 249°-253° [Hydrochloride salt form].

Workup

  1. additionare added dropwise
  2. waitthe solution left
  3. customThe reaction solution is finally evaporated to dryness
  4. washwashed with IN sodium carbonate solution
  5. customdried
  6. customevaporated to dryness

Sources & evidence

ORD record
ord-f0faeb8257a648e397093d24e5e26ca1
Source dataset
uspto-grants-1981_12
Patent number
US04308266

Reaction notes

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