反应详情

170 mg of 1,2,3,4-tetrahydro-6-hydroxy-2-[4-(2-methoxyphenyl)-1-piperazinyl]-naphthalene are added to 2 ml of pyridine, 70 μl of acetic anhydride are added dropwise and the solution left to stand at room temperature for 3 hours. The reaction solution is finally evaporated to dryness, the residue taken up in ethyl acetate, washed with IN sodium carbonate solution, dried and evaporated to dryness. The raw title product so obtained is converted to the hydrochloride salt form and recrystallized from methanol/ether. M.P. 249°-253° [Hydrochloride salt form].

1. additionare added dropwise
2. waitthe solution left
3. customThe reaction solution is finally evaporated to dryness
4. washwashed with IN sodium carbonate solution
5. customdried
6. customevaporated to dryness