N-Methylcyclohexylamine → HCID 20556834, compound

Participants

Reaction Steps

To 2.0 g. of 3-phenyl-6-tosyloxymethyl-5,6-dihydro-4H-1,2,4-oxadiazine 30 ml. of chlorobenzene and 3 ml. of methylcyclohexyl amine are added and the reaction mixture is refluxed for 6 hours. The mixture is then cooled down and the precipitated product is filtered off, dissolved in ethyl acetate and the solution is acidified with hydrochloric acid in ethanol. 1.1 g. of 3-phenyl-6-(N-methyl-N-cyclohexylamino)-methyl-5,6-dihydro-4H-1,2,4-oxadiazine dihydrochloride are obtained, which has the same properties as the product of Example 2.

Provenance & Evidence