1,2,3,4-Tetrahydroisoquinoline → HCID 20556841, compound

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Reaction Steps

To 3.46 g. of 3-phenyl-6-tosyloxymethyl-5,6-dihydro-4H-1,2,4-oxadiazine 1.33 g. of 1,2,3,4-tetrahydro-isoquinoline, 1.38 g. of anhydrous potassium carbonate and 30 ml. of chlorobenzene are added. The reaction mixture is refluxed for 2 hours, whereupon it is decolored and filtered while hot. Upon cooling 1.95 g. of 3-phenyl-6-(1,2,3,4-tetrahydro-2-isoquinolyl)-methyl-5,6-dihydro-4H-1,2,4-oxadiazine are obtained in crystalline form. The product has the same properties as the product of Example 4. Melting point: 187° to 189° C.

Provenance & Evidence