Ethyl chloroformate → HCID 20556839, compound

Participants

Reaction Steps

To 3.08 g. of 3-phenyl-6-(1,2,3,4-tetrahydro-2-isoquinolyl)-methyl-5,6-dihydro-4H-1,2,4-oxadiazine 50 ml. of absolute acetone, 1.0 ml. of chlorocarbonic acid ethyl ester and 1.0 g. of anhydrous potassium carbonate are added. The reaction mixture is refluxed for 6 hours. The insoluble substances are filtered off while hot and the solvent is evaporated. After recrystallization of the residue from cyclohexane 1.18 g. of 3-phenyl-4-ethoxycarbonyl-6-(1,2,3,4-tetrahydro-2-isoquinolyl)-methyl-5,6-dihydro-1,2,4-oxadiazine are obtained, melting at 114° to 116° C.

Provenance & Evidence