Sulfur trioxide → HCID 20556790, compound

HRID 1660506Notes

Reaction equation

HRID 1660506 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([Cl:11])=[O:10].[S:12](=[O:15])(=[O:14])=[O:13]>ClCCl.ClC(Cl)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([S:12]([OH:15])(=[O:14])=[O:13])[C:9]([Cl:11])=[O:10]

Participants

5

Reactant 2

HCID 24682Sulfur trioxideHCID 140040112-(2-Fluorophenyl)acetyl chloride

Product 1

HCID 20556790HCID 20556790, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 63651,1-DichloroethaneSolvent

Procedure

A solution of 2-(2-fluorophenyl)acetyl chloride (1.73 g, 10 mmole) in dichloromethane (20 ml) was treated with a suspension of sulphur trioxide--dioxane complex (15 mmole) in dichloroethane at 0° C. This mixture was stirred at room temperature for eighteen hours and evaporated to a yellow gum. νmax. (CHCl3) 1805 cm-1.

Workup

  1. customat 0° C
  2. customevaporated to a yellow gum

Sources & evidence

ORD record
ord-5d78f98cf7ac45b9ac963703e2f93a0e
Source dataset
uspto-grants-1981_12
Patent number
US04308259

Reaction notes

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