Ethyl 3-(butanoylamino)-2-oxobutanoate → HCID 178454522, compound

Participants

Reaction Steps

Aminoguanidine bicarbonate (2.4 g) was suspended in a solution of ethyl 3-butyramido-2-oxo-butyrate (3.8 g) in absolute ethanol (40 ml) and the mixture was heated under reflux for 5 hours. During this period aminoguanidine bicarbonate gradually dissolved and a new product precipitated as a white solid. The mixture was cooled and the solid (2.62 g) collected and taken up in 2 N hydrochloric acid (30 ml). The solution was filtered to remove a small amount of undissolved solid, then adjusted to pH 8 by adding solid sodium carbonate. The triazinone separated as a white solid which was collected, washed with water and dried in vacuo at 100° to give material m.p. 308° (dec.), (2.0 g) (50% approx.).

Provenance & Evidence