反应详情

A mixture of cis-(E)-6-[2-(3,5-dichloro-4'-fluoro-2-[1,1'-biphenyl]yl)ethenyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one (7.6 g, 20 mmole) and mercuric chloride (6 g, 22 mmole) was stirred at gentle reflux in H2O--acetonitrile (1:5; V:V; 120 ml) under N2 for 68 hours. The cooled reaction mixture was then diluted with Et2O (1 liter), washed with H2O (3×500 ml), and brine, dried (MgSO4), filtered and evaporated in vacuo to provide the crude title compound (7 g) as a pale amber gum (56% cis and 44% trans by HPLC).

1. customThe cooled reaction mixture
2. washwashed with H2O (3×500 ml), and brine
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. customevaporated in vacuo