反应详情

6.63 g (58.1 mmol) of potassium tert-butoxide and then 8.50 g (25.7 mmol) of 10-phenylphenothiazine-3,7-dicarbaldehyde were added at room temperature with stirring to a solution of 15.61 g (51.3 mmol) of diethyl benzhydrylphosphonate (prepared analogously to Example 13 in U.S. Pat. No. 5,130,603) in 121 ml of dimethyl sulfoxide dried over molecular sieve. After stirring at room temperature for 5 hours, the reaction solution was diluted with 1500 ml of methanol and stirred for a further 15 min. The precipitate was filtered off, washed with methanol and dried at 80° C. under reduced pressure. 6.92 g (43% of theory) of yellowish solid having a melting point of 232-237° C. were obtained.

1. customprepared analogously to Example 13 in U.S
2. dry with material5,130,603) in 121 ml of dimethyl sulfoxide dried over molecular sieve
3. additionthe reaction solution was diluted with 1500 ml of methanol
4. stirringstirred for a further 15 min
5. filtrationThe precipitate was filtered off
6. washwashed with methanol
7. customdried at 80° C. under reduced pressure
8. customwere obtained