HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 5-Bromo-4-(trifluoromethyl)thiazol-2-amine hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 2-Thiazolamine, 4-(trifluoromethyl)- | HCID 1201417 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 5-Bromo-4-(trifluoromethyl)thiazol-2-amine hydrobromide | HCID 84819866 | 162.9% |
Reaction Steps
Add bromine (2.0 mL, 6.28 g, 39.3 mmol) dropwise to an ice-bath cooled solution of 4-trifluoromethyl-thiazole-2-ylamine (6.0 g, 35.7 mmol) in diethyl ether (60 mL). Stir for one hour after the addition is complete and then warm to room temperature. Collect the solids by filtration and wash with diethyl ether to obtain the title compound (10.5 g, 90%). ES/MS m/z (79Br/81Br) 247/249 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030304B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-146c10c20dc945cfbdb74ab377e18acf |
| Source note | uspto-grants-2011_10 |