Ether hydrochloride → Evogliptin hydrochloride

Participants

Reaction Steps

97 mg of tert-butyl (R)-4-[(R)-2-(tert-butoxymethyl)-3-oxopiperazin-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate prepared in Step 8 was dissolved in 3 mL of methanol, followed by addition of 2 mL of 2N-hydrochloric acid/diethyl ether and stirring at room temperature for 3 hours. The reaction mixture was concentrated and dried under reduced pressure to afford 64 mg of the title compound as a foamy solid.

Provenance & Evidence