Sodium Bicarbonate → Evogliptin

Participants

Reaction Steps

60 mg of the compound obtained in Example 1 was added to 10 mL of a 5% sodium hydrogen carbonate aqueous solution, and the mixture was extracted two times with 10 mL of a mixed solution of dichloromethane/2-propanol (4/1(v/v)). The organic layer was dried under reduced pressure to afford 55 mg of the title compound as a solid.

Provenance & Evidence