HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1660805Generated: October 26, 2026
Thionyl Chloride → 4-Benzyloxy-3-nitro-benzoyl chloride
https://huagongshe.com/reaction/1660805
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-(Benzyloxy)-3-nitrobenzoic acid | HCID 16124725 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Benzyloxy-3-nitro-benzoyl chloride | HCID 20454288 | — |
Reaction Steps
A suspension of 4-benzyloxy-3-nitro-benzoic acid (36 g, 132 mmol) in toluene (1000 mL) and dimethylformamide (3 mL) was treated with thionyl chloride (47 g, 28.7 mL, 395 mmol) and stirred at 90° C. for 18 hours. The volatiles were evaporated completely and the residue dried under high vacuum. 4-Benzyloxy-3-nitro-benzoyl chloride thus obtained (37.5 g, 97%) was used crude in the following reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08030308B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-023e7b65d8e44908b7a231ed88271024 |
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| Source note | uspto-grants-2011_10 |
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