HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-methoxybenzene-1-sulfonyl chloride → 3-(5-Chloro-2-methoxy-benzenesulfonylamino)-4-hydroxy-5-trifluoromethyl-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-methoxybenzene-1-sulfonyl chloride | HCID 2734272 | — |
| Reactant | 3-Amino-4-hydroxy-5-trifluoromethyl-benzoic acid methyl ester | HCID 66789397 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-(5-Chloro-2-methoxy-benzenesulfonylamino)-4-hydroxy-5-trifluoromethyl-benzoic acid methyl ester | HCID 66788674 | — |
Reaction Steps
A suspension of 3-amino-4-hydroxy-5-trifluoromethyl-benzoic acid methyl ester (4.66 g, 19.8 mmol) and 5-chloro-2-methoxybenzenesulfonyl chloride (4.78 g, 19.8 mmol) in toluene (38 mL) was heated at reflux for 48 h. After cooling, the precipitate was collected by filtration and washed with toluene to afford 3-(5-chloro-2-methoxy-benzenesulfonylamino)-4-hydroxy-5-trifluoromethyl-benzoic acid methyl ester. Off-white solid, MS (ISP)=438.0 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030308B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-ed296ae9e1314fc1a8963f7606fa720d |
| Source note | uspto-grants-2011_10 |