Benzocaine → HCID 66788838, compound

HRID 1660830Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:27][CH3:28])=[C:6]([S:8]([N:11]2[C:15]3[CH:16]=[C:17]([C:24]([OH:26])=O)[CH:18]=[C:19]([C:20]([F:23])([F:22])[F:21])[C:14]=3[O:13][CH2:12]2)(=[O:10])=[O:9])[CH:7]=1.[NH2:29][C:30]1[CH:40]=[CH:39][C:33]([C:34]([O:36][CH2:37][CH3:38])=[O:35])=[CH:32][CH:31]=1>>[CH2:37]([O:36][C:34](=[O:35])[C:33]1[CH:39]=[CH:40][C:30]([NH:29][C:24]([C:17]2[CH:18]=[C:19]([C:20]([F:22])([F:23])[F:21])[C:14]3[O:13][CH2:12][N:11]([S:8]([C:6]4[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=4[O:27][CH3:28])(=[O:9])=[O:10])[C:15]=3[CH:16]=2)=[O:26])=[CH:31][CH:32]=1)[CH3:38]

Participants

Reactant 2

HCID 2337Benzocaine

HCID 66789614HCID 66789614, compound

Product 1

HCID 66788838HCID 66788838, compound

Procedure

Reaction of 3-(5-chloro-2-methoxy-benzenesulfonyl)-7-trifluoromethyl-2,3-dihydro-benzooxazole-5-carboxylic acid with ethyl 4-aminobenzoate in analogy with example 30, step 4 gave 4-{[3-(5-chloro-2-methoxy-benzenesulfonyl)-7-trifluoromethyl-2,3-dihydro-benzooxazole-5-carbonyl]-amino}-benzoic acid ethyl ester. Light yellow solid, MS (ISP)=584.9 (M+H)+.

Sources & evidence

ORD record: ord-385cc15f0754464fbafe983a0d1c89ad
Source dataset: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08030308B2

Reaction notes

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