Water → HCID 24762482, compound

HRID 1660865Notes

Reaction equation

HRID 1660865 reaction equation
C([O:5][C:6](=[O:37])[C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([C:16]2[CH:17]=[CH:18][C:19]3[S:24](=[O:25])[CH2:23][CH2:22][N:21]([S:26]([C:29]4[CH:34]=[CH:33][CH:32]=[C:31]([Cl:35])[CH:30]=4)(=[O:28])=[O:27])[C:20]=3[CH:36]=2)=[O:15])=[CH:9][CH:8]=1)(C)(C)C.O>C(O)=O>[Cl:35][C:31]1[CH:30]=[C:29]([S:26]([N:21]2[C:20]3[CH:36]=[C:16]([C:14]([NH:13][C:10]4[CH:11]=[CH:12][C:7]([C:6]([OH:37])=[O:5])=[CH:8][CH:9]=4)=[O:15])[CH:17]=[CH:18][C:19]=3[S:24](=[O:25])[CH2:23][CH2:22]2)(=[O:27])=[O:28])[CH:34]=[CH:33][CH:32]=1

Participants

4

Reactant 2

HCID 962WaterHCID 66788875HCID 66788875, compound

Product 1

HCID 24762482HCID 24762482, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A suspension of 4-{[4-(3-chloro-benzenesulfonyl)-1-oxo-1,2,3,4-tetrahydro-benzo[1,4]thiazine-6-carbonyl]-amino}-benzoic acid tert-butyl ester (153 mg, 0.273 mmol) in formic acid (4 mL) was stirred for 16 h at room temperature, then the solution obtained was treated with water, and the suspension was stirred for another 90 min. The precipitate was collected by filtration and dried to produce the title compound (126 mg, 92%). White solid, 505.2 (M+H)+.

Workup

  1. customthe solution obtained
  2. stirringthe suspension was stirred for another 90 min
  3. filtrationThe precipitate was collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-5e63742a87654f58b7344abac9c88760
Source dataset
uspto-grants-2011_10
Patent number
US08030308B2

Reaction notes

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