Benzoic acid, 4-amino-, 1,1-dimethylethyl ester → HCID 50991078, compound

HRID 1660866Notes

Reaction equation

HRID 1660866 reaction equation
CC1C=C(S(N2C3C=C(C(O)=O)C=CC=3SCC2)(=O)=O)C=C(C)C=1.NC1C=CC(C(OC(C)(C)C)=O)=CC=1.C([O:43][C:44](=[O:75])[C:45]1[CH:50]=[CH:49][C:48]([NH:51][C:52]([C:54]2[CH:55]=[CH:56][C:57]3[S:62][CH2:61][CH2:60][N:59]([S:63]([C:66]4[CH:71]=[C:70]([CH3:72])[CH:69]=[C:68]([CH3:73])[CH:67]=4)(=[O:65])=[O:64])[C:58]=3[CH:74]=2)=[O:53])=[CH:47][CH:46]=1)(C)(C)C>>[CH3:73][C:68]1[CH:67]=[C:66]([S:63]([N:59]2[C:58]3[CH:74]=[C:54]([C:52]([NH:51][C:48]4[CH:47]=[CH:46][C:45]([C:44]([OH:75])=[O:43])=[CH:50][CH:49]=4)=[O:53])[CH:55]=[CH:56][C:57]=3[S:62][CH2:61][CH2:60]2)(=[O:65])=[O:64])[CH:71]=[C:70]([CH3:72])[CH:69]=1

Participants

4

Reactant 3

HCID 233272Benzoic acid, 4-amino-, 1,1-dimethylethyl esterHCID 66789164HCID 66789164, compoundHCID 66789635HCID 66789635, compound

Product 1

HCID 50991078HCID 50991078, compound

Procedure

Reaction of 4-(3,5-dimethyl-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid with tert-butyl 4-aminobenzoate in accordance with the general method of example 30, step 4 produced 4-{[4-(3,5-dimethyl-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]thiazine-6-carbonyl]-amino}-benzoic acid tert-butyl ester. White solid, MS (ISP)=539.3 (M+H)+.

Sources & evidence

ORD record
ord-c0ac235e50fe4b2a8e3d3255d0345746
Source dataset
uspto-grants-2011_10
Patent number
US08030308B2

Reaction notes

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