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1-Bromo-2-propanol → 5-(2-Fluoro-4-iodophenylamino)-3-(2-hydroxypropyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Bromo-2-propanol | HCID 29740 | — |
| 反応物 | (S)-3-(2,3-Dihydroxypropyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione | HCID 24965731 | — |
| 反応物 | 5-((4-Amino-2-fluorophenyl)amino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione | HCID 135741654 | — |
| 生成物 | 5-(2-Fluoro-4-iodophenylamino)-3-(2-hydroxypropyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione | HCID 24967883 | — |
反応手順
The title compound was prepared following the same procedure for the synthesis of Compound 5G using compound 5F and 1-bromopropan-2-ol as starting material. 1H NMR (400 MHz, CDCl3) δ 8.17 (s, 1H) 7.52 (m, 2H) 7.24 (t, J=8.84 Hz, 1H) 5.81 (s, 1H) 4.39 (m, 1H) 4.25 (m, 1H) 3.57 (m, 4H), 1.35 (d, J=6.32 Hz, 3H). [M+H] calc'd for C17H16FIN4O3, 471; found, 471.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08030317B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-0bc056e859364216a77f1ce5b756ff97 |
| 出典メモ | uspto-grants-2011_10 |