Sodium Nitrite → HCID 67429579, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 3-amino-8-chloro-1H-benzo[4,5]furo[3,2-d]pyrimidine-2,4-dione (2.9 g, 11.6 mmol) in 1:1 mixture of acetic acid/H2O (200 mL) was added NaNO2 (2.5 g, 36.0 mmol). The reaction mixture was heated at 45-50° C. until the evolution of brown fumes ceased (2 h). The product was collected by filtration to afford 2.45 g (89%) of the desired product.

Provenance & Evidence