Ethyl orthoformate → HCID 67021375, compound

Participants

Reaction Steps

A mixture of [4-(3-amino-pyridin-4-ylamino)-phenyl]-acetic acid methyl ester (0.356 g, 1.39 mmol) and triethyl orthoformate (9.2 mL, 55.4 mmol, 40 equiv) is stirred and refluxed for 2 h. The resulting mixture is allowed to cool to rt and concentrated in vacuo to provide the title compound as a beige solid: ES-MS: 268.1 [M+H]+; single peak at tR=2.03 min (System 1).

Provenance & Evidence