(4-Imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid → HCID 11993477, compound

HRID 1660939Notes

Reaction equation

HRID 1660939 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[C:5]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][C:8]([NH2:15])=[CH:7][CH:6]=1.[N:19]1[C:27]2[C:22](=[N:23][CH:24]=[CH:25][CH:26]=2)[N:21]([C:28]2[CH:33]=[CH:32][C:31]([CH2:34][C:35](O)=[O:36])=[CH:30][CH:29]=2)[CH:20]=1>C(Cl)Cl.CO>[Br:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[C:5]1[C:10]([C:11]([F:13])([F:14])[F:12])=[CH:9][C:8]([NH:15][C:35](=[O:36])[CH2:34][C:31]2[CH:30]=[CH:29][C:28]([N:21]3[C:22]4=[N:23][CH:24]=[CH:25][CH:26]=[C:27]4[N:19]=[CH:20]3)=[CH:33][CH:32]=2)=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 53213084(4-Imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acidHCID 59864214HCID 59864214, compound

Product 1

HCID 11993477HCID 11993477, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 1 but using 3′-bromo-2-trifluoromethyl-biphen-4-ylamine and (4-imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid. Title compound: ES-MS: 552.8 [M+H]+; tR=5.24 min (System 1); Rf=0.20 (CH2Cl2/MeOH, 96:4).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-093e61facfed4ed7b80040ed8d4cabec
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

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