(4-Imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid → N-{4-[(3-Dimethylamino-propyl)-methyl-amino]-3-trifluoromethyl-phenyl}-2-(4-imidazo[4,5-b]pyridin-3-yl-phenyl)-acetamide

HRID 1660946Notes

Reaction equation

HRID 1660946 reaction equation
[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=O)=[CH:12][CH:11]=2)[CH:2]=1.[CH3:20][N:21]([CH3:38])[CH2:22][CH2:23][CH2:24][N:25]([CH3:37])[C:26]1[CH:31]=[CH:30][C:29]([NH2:32])=[CH:28][C:27]=1[C:33]([F:36])([F:35])[F:34]>>[CH3:38][N:21]([CH3:20])[CH2:22][CH2:23][CH2:24][N:25]([CH3:37])[C:26]1[CH:31]=[CH:30][C:29]([NH:32][C:17](=[O:19])[CH2:16][C:13]2[CH:12]=[CH:11][C:10]([N:3]3[C:4]4=[N:5][CH:6]=[CH:7][CH:8]=[C:9]4[N:1]=[CH:2]3)=[CH:15][CH:14]=2)=[CH:28][C:27]=1[C:33]([F:34])([F:36])[F:35]

Participants

3

Reactant 2

HCID 53213084(4-Imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acidHCID 63695501HCID 63695501, compound

Product 1

HCID 11993481N-{4-[(3-Dimethylamino-propyl)-methyl-amino]-3-trifluoromethyl-phenyl}-2-(4-imidazo[4,5-b]pyridin-3-yl-phenyl)-acetamide

Procedure

The title compound is prepared as described in Example 1 but using (4-imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid (Step 7.1) and 4-[(3-dimethylamino-propyl)-methyl-amino]-3-trifluoromethyl-phenylamine (Step 5.1). Title compound: ES-MS: 511.0 [M+H]+; single peak at tR=3.33 min (System 1).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-cb1ba8164f1e4dbd82e20c58a8a3117b
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

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