(4-Imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid → HCID 11993578, compound

HRID 1660950Notes

Reaction equation

HRID 1660950 reaction equation
[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=O)=[CH:12][CH:11]=2)[CH:2]=1.[CH3:20][O:21][C:22]1[CH:38]=[CH:37][C:25]([C:26]2[CH:27]=[C:28]([C:33]([F:36])([F:35])[F:34])[CH:29]=[C:30]([NH2:32])[CH:31]=2)=[CH:24][CH:23]=1>CCCCCC.CCOC(C)=O>[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[CH:11]=[CH:12][C:13]([CH2:16][C:17]([NH:32][C:30]3[CH:31]=[C:26]([C:25]4[CH:37]=[CH:38][C:22]([O:21][CH3:20])=[CH:23][CH:24]=4)[CH:27]=[C:28]([C:33]([F:34])([F:35])[F:36])[CH:29]=3)=[O:19])=[CH:14][CH:15]=2)[CH:2]=1

Participants

4

Reactant 2

HCID 53213084(4-Imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acidHCID 131729209HCID 131729209, compound

Product 1

HCID 11993578HCID 11993578, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The title compound is prepared as described in Example 1 but using (4-imidazo[4,5-b]pyridin-3-yl-phenyl)acetic acid (Step 7.1) and 4′-methoxy-5-trifluoromethyl-biphen-3-ylamine. Title compound: ES-MS: 502.9 [M+H]+; tR=5.00 min (System 1); Rf=0.21 (Hexane/EtOAc, 1:4).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-c6255d8dd6154759aed53c93b9b89ee2
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

Loading…