(4-Imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid → HCID 11993579, compound

HRID 1660952Notes

Reaction equation

HRID 1660952 reaction equation
[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=O)=[CH:12][CH:11]=2)[CH:2]=1.[CH3:20][N:21]([CH:33]1[CH2:38][CH2:37][N:36]([CH3:39])[CH2:35][CH2:34]1)[C:22]1[CH:27]=[CH:26][C:25]([NH2:28])=[CH:24][C:23]=1[C:29]([F:32])([F:31])[F:30]>C(Cl)Cl.CO>[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[CH:11]=[CH:12][C:13]([CH2:16][C:17]([NH:28][C:25]3[CH:26]=[CH:27][C:22]([N:21]([CH3:20])[CH:33]4[CH2:34][CH2:35][N:36]([CH3:39])[CH2:37][CH2:38]4)=[C:23]([C:29]([F:32])([F:30])[F:31])[CH:24]=3)=[O:19])=[CH:14][CH:15]=2)[CH:2]=1

Participants

4

Reactant 2

HCID 53213084(4-Imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acidHCID 60925354HCID 60925354, compound

Product 1

HCID 11993579HCID 11993579, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 1 but using (4-imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid (Step 7.1) and 4-[methyl-(1-methyl-piperidin-4-yl)-amino]-3-trifluoromethyl-phenylamine. Title compound: ES-MS: 523.0 [M+H]+; single peak at tR=3.33 min (System 1); Rf=0.18 (CH2Cl2/MeOH+1% NH3aq, 9:1).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-1e2984e89d264d9a844cda689bcce023
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

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