4-(4-Isopropylpiperazin-1-ylmethyl)-3-trifluoromethyl-aniline → 2-(2-Chloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-N-[4-(4-isopropyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-acetamide

Participants

Role	Name	HCID	Charge
Reactant	4-(4-Isopropylpiperazin-1-ylmethyl)-3-trifluoromethyl-aniline	HCID 57431445	—
Reactant	(2-Chloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid	HCID 67021590	—
Solvent	Dichloromethane methanol	HCID 21226129	—
Product	2-(2-Chloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-N-[4-(4-isopropyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-acetamide	HCID 11993580	—

Reaction Steps

The title compound is prepared as described in Example 1 but using (2-chloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid and 4-(4-isopropyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenylamine (see WO 03/099771). Title compound: ES-MS: 570.9 [M+H]+; single peak at tR=3.46 min (System 1); Rf=0.26 (CH2Cl2/MeOH+1% NH3aq, 9:1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08030311B2
Source dataset	uspto-grants-2011_10
ORD ID	ord-175989b64a214e42bef58b88a7431977
Source note	uspto-grants-2011_10