HRID1660961

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID63695501

未命名化合物

HCID67021590

未命名化合物

PRODUCTS

生成物

结构：CN(C)CCCN(C)c1ccc(NC(=O)Cc2ccc(-n3cnc4cccnc43)cc2Cl)cc1C(F)(F)F

HCID11993678

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21226129

未命名化合物

PROCEDURE

实验过程

The title compound is prepared as described in Example 1 but using (2-chloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid (Step 16.1) and 4-[(3-dimethylamino-propyl)-methyl-amino]-3-trifluoromethyl-phenylamine (Step 5.1). Title compound: ES-MS: 544.9 [M+H]+; single peak at tR=3.66 min (System 1); Rf=0.28 (CH2Cl2/MeOH+1% NH3aq, 9:1).

WORKUP

后处理

customThe title compound is prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-54d4d31fa2ef4a4ea53b280eee111747
来源数据集: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08030311B2
来源说明: uspto-grants-2011_10

反应 SMILES

[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[C:12]3=[N:13][CH:14]=[CH:15][CH:16]=[C:11]3[N:10]=[CH:9]2)[CH:5]=[CH:4][C:3]=1[CH2:17][C:18]([OH:20])=O.[CH3:21][N:22]([CH3:39])[CH2:23][CH2:24][CH2:25][N:26]([CH3:38])[C:27]1[CH:32]=[CH:31][C:30]([NH2:33])=[CH:29][C:28]=1[C:34]([F:37])([F:36])[F:35]>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[C:12]3=[N:13][CH:14]=[CH:15][CH:16]=[C:11]3[N:10]=[CH:9]2)[CH:5]=[CH:4][C:3]=1[CH2:17][C:18]([NH:33][C:30]1[CH:31]=[CH:32][C:27]([N:26]([CH2:25][CH2:24][CH2:23][N:22]([CH3:21])[CH3:39])[CH3:38])=[C:28]([C:34]([F:35])([F:36])[F:37])[CH:29]=1)=[O:20]