4-Aminophenylacetic acid → HCID 67021624, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-nitrofluorobenzene (1.5 mL, 14.2 mmol, 1.5 equiv) (Aldrich), 4-aminophenyl acetic acid (1.44 g, 9.5 mmol), and KF (0.550 g, 9.5 mmol) is stirred at 170° C. for 16 h in a sealed tube. The reaction mixture is then allowed to cool to rt, triturated in CH2Cl2/MeOH (95:5) and filtered, and the filtrate is concentrated. The residue is purified by silica gel column chromatography (CH2Cl2/MeOH, 97:3→95:5) to provide the title compound as a red solid: ES-MS: 273.0 [M+H]+; single peak at tR=4.44 min (System 1); Rf=0.20 (CH2Cl2/MeOH, 95:5).

Provenance & Evidence