HCID 59725939, compound → HCID 11993682, compound

HRID 1660967Notes

Reaction equation

HRID 1660967 reaction equation
[N:1]1([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=O)=[CH:12][CH:11]=2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH3:20][N:21]([CH3:37])[CH2:22][CH2:23][N:24]([CH3:36])[C:25]1[CH:30]=[CH:29][C:28]([NH2:31])=[CH:27][C:26]=1[C:32]([F:35])([F:34])[F:33]>C(Cl)Cl.CO>[N:1]1([C:10]2[CH:11]=[CH:12][C:13]([CH2:16][C:17]([NH:31][C:28]3[CH:29]=[CH:30][C:25]([N:24]([CH2:23][CH2:22][N:21]([CH3:37])[CH3:20])[CH3:36])=[C:26]([C:32]([F:33])([F:34])[F:35])[CH:27]=3)=[O:19])=[CH:14][CH:15]=2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 59725939HCID 59725939, compoundHCID 67021617HCID 67021617, compound

Product 1

HCID 11993682HCID 11993682, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 1 but using (4-benzoimidazol-1-yl-phenyl)-acetic acid (Step 20.1) and 4-[(2-dimethylamino-ethyl)-methyl-amino]-3-trifluoromethyl-phenylamine (Step 6.1). Title compound: ES-MS: 496.0 [M+H]+; single peak at tR=3.00 min (System 1); Rf=0.14 (CH2Cl2/MeOH+1% NH3aq, 9:1).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-76b02930889d41fc9c4bf2eb1bf62a9e
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

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