HCID 67021352, compound → HCID 11992233, compound

HRID 1660968Notes

Reaction equation

HRID 1660968 reaction equation
[N:1]1([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=O)=[CH:12][CH:11]=2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[NH2:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:32]=[CH:31][C:30]([C:33]#[N:34])=[CH:29][CH:28]=2)=[C:23]([C:35]([F:38])([F:37])[F:36])[CH:22]=1>C(Cl)Cl.CO>[N:1]1([C:10]2[CH:11]=[CH:12][C:13]([CH2:16][C:17]([NH:20][C:21]3[CH:22]=[C:23]([C:35]([F:36])([F:37])[F:38])[C:24]([C:27]4[CH:32]=[CH:31][C:30]([C:33]#[N:34])=[CH:29][CH:28]=4)=[CH:25][CH:26]=3)=[O:19])=[CH:14][CH:15]=2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 67021352HCID 67021352, compoundHCID 67021617HCID 67021617, compound

Product 1

HCID 11992233HCID 11992233, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 1 but using (4-benzoimidazol-1-yl-phenyl)-acetic acid (Step 20.1) and 4′-amino-2′-trifluoromethyl-biphenyl-4-carbonitrile. Title compound: ES-MS: 496.9 [M+H]+; single peak at tR=4.37 min (System 1); Rf=0.12 (CH2Cl2/MeOH, 96:4).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-53d5c414c28546849246bb6037f6cf0e
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

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