AP-24592 → 2-{4-[5-(4-Methoxy-phenyl)-benzoimidazol-1-yl]-phenyl}-N-[4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-acetamide

Participants

Role	Name	HCID	Charge
Reactant	AP-24592	HCID 46838908	—
Reactant	{4-[5-(4-Methoxyphenyl)-benzoimidazol-1-yl]-phenyl}-acetic acid	HCID 67021579	—
Solvent	Dichloromethane methanol	HCID 21226129	—
Product	2-{4-[5-(4-Methoxy-phenyl)-benzoimidazol-1-yl]-phenyl}-N-[4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-acetamide	HCID 11993288	—

Reaction Steps

The title compound is prepared as described in Example 1 but using {4-[5-(4-methoxy-phenyl)-benzoimidazol-1-yl]-phenyl}-acetic acid and 4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenylamine (WO 03/099771). Title compound: ES-MS: 613.9 [M+H]+; single peak at tR=3.56 min (System 1); Rf=0.10 (CH2Cl2/MeOH+1% NH3aq, 9:1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08030311B2
Source dataset	uspto-grants-2011_10
ORD ID	ord-53d6cf6fed1641c79fb8773b3cbb70a5
Source note	uspto-grants-2011_10