HCID 67021331, compound → HCID 67021591, compound

Participants

Reaction Steps

A suspension of [4-(4-bromo-2-nitro-phenylamino)-phenyl]-acetic acid ethyl ester (1.0 g, 2.64 mmol) and Raney Ni (˜0.300 g) in EtOH (20 mL) is stirred for 2.5 h at rt, under a hydrogen atmosphere. The reaction mixture is filtered through a pad of Celite and concentrated. Silica gel column chromatography purification (Hexane/EtOAc, 7:3) of the crude product affords the title compound as a pale pink solid: ES-MS: 351.0 [M+2]+; single peak at tR=4.82 min (System 1); Rf=0.16 (Hexane/EtOAc, 7:3).

Provenance & Evidence