Triethylamine → HCID 67021650, compound

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	3-tert-butyl-1-phenyl-1H-pyrazol-5-amine	HCID 770634	—
Reactant	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
Reactant	(r/s)-5-Imidazo[4,5-b]pyridine-3-yl-3-oxo-indan-1-carboxylic acid	HCID 67021572	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 67021650	HCID 67021650	—

Reaction Steps

HATU (46.7 mg, 0.12 mmol) and triethylamine (29.5 μL, 0.21 mmol) are added to a solution of (R/S)-5-imidazo[4,5-b]pyridine-3-yl-3-oxo-indan-1-carboxylic acid (30 mg, 0.1 mmol) in DMF (2.5 mL). The reaction is stirred at rt for 2 min then 5-tert-butyl-2-phenyl-2H-pyrazol-3-ylamine (21.5 mg, 0.1 mmol) is added. After stirring at rt for 8 h, DMF is removed in vacuo. The residue is purified by reversed phase MPLC using ACN/Water as eluant and 5-imidazo[4,5-b]pyridine-3-yl-3-oxo-indan-1-carboxylic acid (5-tert-butyl-2-phenyl-2H-pyrazol-3-yl)-amide is obtained as a white solid. Title compound: ES-MS: 491.00 [M+H]+, tR=1.6 min (System 2).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08030311B2
Source dataset	uspto-grants-2011_10
ORD ID	ord-84f3c78462424790b93bb7442bffda88
Source note	uspto-grants-2011_10