Hydrochloric Acid → HCID 67021571, compound

Participants

Reaction Steps

1M LiOH (1.8 mL, 1.8 mmol) is added to a solution of (R/S)-5-imidazo[4,5-b]pyridine-3-yl-indan-1-carboxylic acid ethyl ester (550 mg, 1.8 mmol) in THF (2 mL). EtOH (2 mL) is added and after 10 min, 1N NaOH (2.5 mL) is added. The mixture is stirred at rt for 1.5 h and then acidified with 1M HCl. Water is added to the reaction mixture and the compound extracted with EtOAc. The organic layers are combined and washed with brine, dried with MgSO4, filtered and concentrated to give (R/S)-5-imidazo[4,5-b]pyridine-3-yl-indan-1-carboxylic acid as a white solid. Title compound: ES-MS: 280.09 [M+H]+; tR=1.0 min (System 2).

Provenance & Evidence