1-Isopropyl-4-(4-nitrobenzyl)piperazine → 4-((4-Isopropylpiperazin-1-yl)methyl)benzenamine

Participants

Reaction Steps

A suspension of 1-isopropyl-4-(4-nitro-benzyl)-piperazine (5.7 g, 21.65 mmol) and Raney Nickel (2 g) in MeOH (100 mL) is stirred for 6 h at rt, under a hydrogen atmosphere. The reaction mixture is filtered through a pad of celite and concentrated to afford 6.3 g of the title compound as a white solid: ESI-MS: 234.1 [M+H]+; tR=0.95 min (System 1).

Provenance & Evidence