Ethyl orthoformate → HCID 67021592, compound

Participants

Reaction Steps

A mixture of [4-(3-amino-pyridin-2-ylamino)-2,6-dichloro-phenyl]-acetic acid methyl ester (4.5 g, 13.8 mmol) and triethyl orthoformate (60 mL, 361 mmol, 26 equiv) is stirred for 13.5 h at reflux. The resulting mixture is allowed to cool to rt and concentrated in vacuo to provide the title compound as a dark solid: ES-MS: 336.0/338.0 [M+H]+; tR=4.58 min (System 1); Rf=0.28 (Hexane/EtOAc, 1:1).

Provenance & Evidence