HCID 67021636, compound → HCID 67021584, compound

Participants

Reaction Steps

A suspension of [2,6-dichloro-4-(3-nitro-pyridin-2-ylamino)-phenyl]-acetic acid methyl ester (5 g, 14.0 mmol) and Raney Ni (˜1 g) in MeOH (100 mL) is stirred for 20 h at rt, under a hydrogen atmosphere. The reaction mixture is filtered through a pad of celite and concentrated to afford the title compound as a grey solid: ES-MS: 326.0/328.0 [M+H]+; tR=3.09 min (System 1); TLC: Rf=0.42 (CH2Cl2/MeOH, 95:5).

Provenance & Evidence