HuagongsheHuagongshe Chemistry Print Report · For research reference only
AP-24592 → 2-(2,6-Dichloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-N-[4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | AP-24592 | HCID 46838908 | — |
| Reactant | (2,6-Dichloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)acetic acid | HCID 67021568 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(2,6-Dichloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-N-[4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-acetamide | HCID 67021626 | — |
Reaction Steps
The title compound is prepared as described in Example 7 but using (2,6-dichloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid (Step 56.1) and 4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenylamine (WO 03/099771). Title compound: ES-MS: 576.8/578.9 [M+H]+; tR=3.72 min (System 1); Rf=0.17 (CH2Cl2/(2N NH3 in MeOH), 95:5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030311B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-d1cc797cf5e545bba3786bfc1138bb4b |
| Source note | uspto-grants-2011_10 |