3-(Trifluoromethyl)aniline → HCID 67021618, compound

HRID 1661030Notes

Reaction equation

HRID 1661030 reaction equation
[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=O)=[C:12]([CH3:20])[CH:11]=2)[CH:2]=1.[F:21][C:22]([F:31])([F:30])[C:23]1[CH:24]=[C:25]([CH:27]=[CH:28][CH:29]=1)[NH2:26]>C(Cl)Cl.CO>[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([NH:26][C:25]3[CH:27]=[CH:28][CH:29]=[C:23]([C:22]([F:21])([F:30])[F:31])[CH:24]=3)=[O:19])=[C:12]([CH3:20])[CH:11]=2)[CH:2]=1

Participants

4

Reactant 2

HCID 73753-(Trifluoromethyl)anilineHCID 67021622(4-Imidazo[4,5-b]pyridin-3-yl-2-methyl-phenyl)-acetic acid

Product 1

HCID 67021618HCID 67021618, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 7 but using (4-imidazo[4,5-b]pyridin-3-yl-2-methyl-phenyl)-acetic acid (Step 60.1) and 3-(trifluoromethyl)aniline. Title compound: ES-MS: 411.1 [M+H]+; tR=4.19 min (System 1); Rf=0.28 (CH2Cl2/MeOH, 95:5+0.1% NH3aq).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-2a85bdaed0dc49158e27d1bd9750c9c7
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

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