853297-25-3 → HCID 59252261, compound

HRID 1661031Notes

Reaction equation

HRID 1661031 reaction equation
[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=O)=[C:12]([CH3:20])[CH:11]=2)[CH:2]=1.[CH3:21][N:22]([CH2:24][C:25]1[CH:30]=[CH:29][C:28]([NH2:31])=[CH:27][C:26]=1[C:32]([F:35])([F:34])[F:33])[CH3:23]>C(Cl)Cl.CO>[CH3:23][N:22]([CH2:24][C:25]1[CH:30]=[CH:29][C:28]([NH:31][C:17](=[O:19])[CH2:16][C:13]2[CH:14]=[CH:15][C:10]([N:3]3[C:4]4=[N:5][CH:6]=[CH:7][CH:8]=[C:9]4[N:1]=[CH:2]3)=[CH:11][C:12]=2[CH3:20])=[CH:27][C:26]=1[C:32]([F:33])([F:35])[F:34])[CH3:21]

Participants

4

Reactant 2

HCID 57431457853297-25-3HCID 67021622(4-Imidazo[4,5-b]pyridin-3-yl-2-methyl-phenyl)-acetic acid

Product 1

HCID 59252261HCID 59252261, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 7 but using (4-imidazo[4,5-b]pyridin-3-yl-2-methyl-phenyl)-acetic acid (Step 60.1) and 4-dimethylaminomethyl-3-trifluoromethyl-phenylamine (disclosed in WO2005/051366). Title compound: ES-MS: 468.2 [M+H]+; tR=2.97 min (System 1); Rf=0.37 (CH2Cl2/MeOH, 9:1+0.1% NH3aq).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-42841a7496df43c280196a9b568b9dc7
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

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