Ethyl orthoformate → [4-(6-Chloro-purin-9-yl)phenyl]-acetic acid ethyl ester

Participants

Reaction Steps

A mixture of [4-(5-amino-6-chloro-pyrimidin-4-ylamino)-phenyl]-acetic acid ethyl ester (0.178 g, 0.58 mmol) and triethyl orthoformate (4 mL, 23.3 mmol, 40 equiv) is stirred for 1 h at reflux. The resulting mixture is allowed to cool to rt and concentrated in vacuo to provide the title compound as a red solid: ES-MS: 317.0 [M+H]+; tR=4.06 min (System 1).

Provenance & Evidence