Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1661041Generated: October 30, 2026

2,3-Dichloro-5-nitropyridine → 1-(3-(3-Chloro-5-nitropyridin-2-yloxy)phenyl)-4-methylpiperazine

https://huagongshe.com/reaction/1661041

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,3-Dichloro-5-nitropyridineHCID 2763106—
Reactant3-(4-Methylpiperazin-1-yl)phenolHCID 11011455—
Product1-(3-(3-Chloro-5-nitropyridin-2-yloxy)phenyl)-4-methylpiperazineHCID 66886341—

Reaction Steps

3-(4-Methylpiperazin-1-yl)phenol was reacted with 2,3-dichloro-5-nitro pyridine (as obtained in preparation 1), to obtain 1-(3-(3-chloro-5-nitropyridin-2-yloxy)phenyl)-4-methylpiperazine which was further converted to the title compound as per the procedure described in preparation 2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08030324B2
Source datasetuspto-grants-2011_10
ORD IDord-6dc50e916ffb4aab8721213dfee08239
Source noteuspto-grants-2011_10