Acetic Acid → HCID 68217607, compound

Participants

Reaction Steps

A mixture of 5-chloro-2,3-dihydro-1H-inden-1-one (150 g, 0.9 mol, commercially available) and ethyl cyanoacetate (125 g, 1.1 mol), ammonium acetate (150 g, 1.94 mmol) and glacial acetic acid (500 mL) in benzene (1 L) was refluxed with a Dean Stark water trap for 22 h. Then benzene was partially removed under vacuum, the residue was filtered and the solid obtain was crystallized from ethanol to give the title compound (161 g, y=68%).

Provenance & Evidence