HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → (E)-ethyl 2-cyano-2-(5-fluoro-2,3-dihydro-1H-inden-1-ylidene)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Ethyl cyanoacetate | HCID 7764 | — |
| Reactant | 5-Fluoro-1-indanone | HCID 136537 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (E)-ethyl 2-cyano-2-(5-fluoro-2,3-dihydro-1H-inden-1-ylidene)acetate | HCID 68217618 | — |
Reaction Steps
A mixture of 5-Fluoro-indan-1-one (150 g, 1 mol, commercially available), and ethyl cyanoacetate (125 g, 1.1 mol), ammonium acetate (154 g, 2 mol) and glacial acetic acid (500 ml) in benzene (1 L) was refluxed with a Dean Stark water trap for 16 h. Then ethyl acetate was added to the reaction mixture and washed with water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030322B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-d831c262bec94f699eeb0b57372db768 |
| Source note | uspto-grants-2011_10 |