HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 5-Chloro-6-methoxy-2,3-dihydrospiro[indene-1,3'-pyrrolidine]-2',5'-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 5-chloro-1-(cyanomethyl)-6-methoxy-2,3-dihydro-1H-indene-1-carbonitrile | HCID 67429293 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 5-Chloro-6-methoxy-2,3-dihydrospiro[indene-1,3'-pyrrolidine]-2',5'-dione | HCID 59233907 | — |
Reaction Conditions
| Temperature | 200 °C |
|---|
Reaction Steps
To a solution of 5-chloro-1-(cyanomethyl)-6-methoxy-2,3-dihydro-1H-indene-1-carbonitrile (Prep17, 520 mg, 2.11 mmol) in AcOH (5.2 ml), H2SO4 (0.364 ml) was added. The mixture was stirred for 15 min at 200° C. Water was added and the mixture extracted with EA twice, solvent was evaporated, dried over Na2SO4, concentrated to give the title compound that was used in the next step without further purification. (540 mg, y=96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030322B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-f5f06d476696481f9c04a317d8e48c82 |
| Source note | uspto-grants-2011_10 |