HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1661061Generated: November 1, 2026
Ethyl 2-chloroacetoacetate → Ethyl 2,4-dimethylthiazole-5-carboxylate
https://huagongshe.com/reaction/1661061
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl 2-chloroacetoacetate | HCID 11858 | — |
| Reactant | Thioacetamide | HCID 2723949 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 2,4-dimethylthiazole-5-carboxylate | HCID 603810 | 83.4% |
Reaction Steps
The mixture of ethyl 2-chloroacetoacetate (111.2 g, 0.68 mol) and thioacetamide (40 g, 0.68 mol) in 150 ml ethanol was heated to 90° C. and stirred for 5 h. After cooling to room temperature, the solvent was removed under vacuum to afford the title compound (105 g, y=83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08030322B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-81d9aaf067124251a646d203f09f0e99 |
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| Source note | uspto-grants-2011_10 |
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