Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl cyanoacetate | HCID 7764 | — |
| Reactant | 6-Chloro-1-indanone | HCID 5100705 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 68217609 | HCID 68217609 | 64.5% |
Reaction Steps
To a solution of 6-chloro-indan-1-one (commercially available, 16 g, 0.1 mol) in Benzene (500 ml), AcOH (160 ml) CH3COONH4 (80 g) and ethyl cyanoacetate (14.4 g, 0.13 mol) were added. The mixture was heated to 100° C. and stirred overnight with a Dean stark water trap. Then ethyl acetate was added and the mixture washed with water. The residue was first purified by FC followed by crystallization from ethanol to obtain the title compound (16.2 g, y=64.5%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08030322B2 |
|---|
| Source dataset | uspto-grants-2011_10 |
|---|
| ORD ID | ord-2465eb315f3b4b46822dda683be35120 |
|---|
| Source note | uspto-grants-2011_10 |
|---|
